- Process for the preparation of 4-oxoimidazolinium salts
-
4-Oxoimidazolinium salts of the general formula: STR1 wherein R1 and R2 independently of one another are C1-10 -alkyl, C2-10 -alkenyl, C3-7 -cycloalkyl or optionally substituted aryl, arylalkyl, heteroaryl or heteroarylalkyl, or R1 and R2, together with the carbon atom to which they are bonded, form a three-membered to seven-membered saturated or unsaturated carbocyclic or heterocyclic ring, R3 is a C1-10 -alkyl group, C1-10 -alkenyl group, C3-7 -cycloalkyl group, aryl group, arylalkyl group or heteroaryl group, and A-- is an anion of a strong acid, are prepared by the cyclization of an α-acylaminonitrile in a nonaqueous solvent, in the presence of a lower alcohol and a strong acid. The compounds are intermediates for pharmaceutical active substances, for example, angiotensin II antagonists.
- -
-
-