Studies on nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological evaluation of pyrazolo [1,5-b][1,2,4]triazole derivatives with alkyl substituents
Alkyl-substituted pyrazolo[1,5-b][1,2,4]triazole derivatives were synthesized and evaluated for activity as angiotensin II receptor antagonists. Molecules with the (methylbiphenylyl)tetrazole moiety at N-5 were the preferred compounds. Ethyl substitutions
This invention relates to a pyrazolotriazole derivative represented by the general formula: STR1 wherein each symbol means as follows; R1, R3 and R4 : one of them represents hydrogen, tetrazolylated biphenylmethyl or lower
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(2008/06/13)
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