151587-55-2Relevant articles and documents
Process for preparing 2-pyrrolidinyl-1H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside metabolism
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Page column 10-11, (2008/06/13)
A process of preparing a compound of the formula (I) wherein B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted all, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof, which comprises reacting a compound of the formula (II) ?with an anion produced by abstraction of the bromine or iodine atom from a compound of formula (XIX), ?to form a compound of formula (XX) The compound of formula (XX) is N- and O-deprotected to obtain the compound of formula (I).
Pyrrolopyrimidine Folate Analogues: "Inverted" Analogues of the Cytotoxic Agent LY231514
Taylor, Edward C.,Young, Wendy B.
, p. 7947 - 7952 (2007/10/03)
N-pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid (3a) and N-pyrimidin-5-yl)propyl>benzoyl>-L-glutamic acid (3b) were synthesized as potential anticancer agents.
An expeditious synthesis of 2-amino-4(3H)-oxo-5H-pyrrolo[3,2-d]pyrimidine (9-deazaguanine)
Taylor,Young,Ward
, p. 4595 - 4598 (2007/10/02)
9-Deazaguanine has been synthesized in five steps from 2-amino-6-methyl-5-nitro-4(3H)-pyrimidinone by a modification of the Batcho-Leimgruber indole synthesis.