Synthesis and biological evaluation of novel turn-modified gramicidin S analogues
The synthesis of novel gramicidin S analogues having additional functionalities in the turn region by employing a biomimetic approach is described. The preservation of β-sheet character in all analogues was established by NMR and the biological activity was evaluated.
Grotenbreg, Gijsbert M.,Spalburg, Emile,De Neeling, Albert J.,Van Der Marel, Gijsbert A.,Overkleeft, Herman S.,Van Boom, Jacques H.,Overhand, Mark