Aziridine-2-carboxylic acid derivatives and its open-ring isomers as a novel PDIA1 inhibitors
[Figure not available: see fulltext.] Acyl derivatives of aziridine-2-carboxylic acid have been synthesized and tested as PDIA1 inhibitors. Calculations of charge value and distribution in aziridine ring system and some alkylating agents were performed. For the first time was found that acyl derivatives of aziridine-2-carboxylic acid are weak to moderately active PDIA1 inhibitors.
Candida cylindracea Lipase-Catalysed Hydrolysis of Methyl Aziridine-2-carboxylates and 2,3-dicarboxylates
N-Substituted aziridine-2-carboxylates and 2,3-dicarboxylates have been resolved with good to excellent stereochemical purity by enzymatic hydrolysis catalysed by lipase from Candida cylindracea.
Bucciarelli, Maria,Forni, Arrigo,Moretti, Irene,Prati, Fabio,Torre, Giovanni
p. 3041 - 3046
(2007/10/02)
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