Design and synthesis of phenylpyrrolidine phenylglycinamides as highly potent and selective TF-FVIIa inhibitors
Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benz
Zhang, Xiaojun,Jiang, Wen,Jacutin-Porte, Swanee,Glunz, Peter W.,Zou, Yan,Cheng, Xuhong,Nirschl, Alexandra H.,Wurtz, Nicholas R.,Luettgen, Joseph M.,Rendina, Alan R.,Luo, Gang,Harper, Timothy M.,Wei, Anzhi,Anumula, Rushith,Cheney, Daniel L.,Knabb, Robert M.,Wong, Pancras C.,Wexler, Ruth R.,Priestley, E. Scott
supporting information
p. 188 - 192
(2014/03/21)
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