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152099-78-0

1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID is a chemical compound that belongs to the barbituric acid class of drugs. It is a derivative of barbituric acid with an additional hydroxyethyl group and a methyl group attached to the nitrogen atom. 1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID is likely to exhibit sedative, hypnotic, and anti-anxiety effects, similar to other barbiturates. As central nervous system depressants, barbiturates have been historically used for their sedative and anesthetic properties, although their medical use has diminished due to the availability of safer and more effective alternatives and the potential for abuse and overdose.

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  • 152099-78-0 Structure

  • Basic information

    1. Product Name: 1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID
    2. Synonyms: 1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID;1-((2-Hydroxyethoxy)methyl)pyrimidine-2,4,6(1H,3H,5H)-trione;1-[(2-Hydroxyethoxy)methyl]-2,4,6(1H,3H,5H)-pyrimidinetrione
    3. CAS NO:152099-78-0
    4. Molecular Formula: C7H10N2O5
    5. Molecular Weight: 202.16
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 152099-78-0.mol

  • Chemical Properties

    1. Melting Point: 147-148℃
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.433±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 4.46±0.40(Predicted)
    10. CAS DataBase Reference: 1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID(152099-78-0)
    12. EPA Substance Registry System: 1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID(152099-78-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 152099-78-0(Hazardous Substances Data)

152099-78-0 Usage

Uses

Used in Pharmaceutical Industry:
1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID is used as a sedative for its potential calming effects on the central nervous system, helping to alleviate anxiety and promote relaxation.
1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID is used as a hypnotic to induce sleep, particularly in cases of insomnia, due to its ability to depress the central nervous system and promote drowsiness.
1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID is used as an anti-anxiety agent to reduce anxiety levels, providing a sense of calm and relaxation in stressful situations.

Check Digit Verification of cas no

The CAS Registry Mumber 152099-78-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,0,9 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 152099-78:
(8*1)+(7*5)+(6*2)+(5*0)+(4*9)+(3*9)+(2*7)+(1*8)=140
140 % 10 = 0
So 152099-78-0 is a valid CAS Registry Number.

152099-78-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-HYDROXYETHOXY)METHYL-5-BARBITURIC ACID

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:152099-78-0 SDS

152099-78-0Downstream Products

152099-78-0Relevant articles and documents

Azines and azoles. CXX. Synthesis of acyclic analogs of N 1-ribosides of barbituric acid and its 5-ylidene derivatives

Studentsov,Kokhanovskii,Ganina,Nikolaeva,Fedorova,Moskvin,Ivin

, p. 261 - 265 (2004)

The reaction of 2,4,6-tris(trimethylsiloxy)pyrimidine with 2-oxabutane-1,4-diyl diacetate in methylene chloride in methylene chloride in the presence of SnCl4 proceeds regioselectively to form 1-[(2-acetoxyethoxy)methyl]barbituric acid. The latter is readily deacetylated to a free acyclic analog of N-ribosides of barbituric acid. 1-[(2-Acetoxy- and 2-hydroxyethoxy)methyl]barbituric acids easily react with aromatic and heterocyclic aldehydes in water and organic solvents, forming 5-ylidenebarbituric acids. The structure of the products was proved by 1H NMR and UV spectroscopy. Certain of the products exhibit a moderate antimicrobial and antiviral activity.

Synthesis of a New Class of Uridine Phoshorylase Inhibitors

Tzeng, Cherng-Chyi,Panzica, Raymond P.,Naguib, Fardos N.M.,Kouni, Mahmoud H. el

, p. 1399 - 1404 (2007/10/02)

A new series of potent uridine phosphorylase inhibitors have been prepared from barbituric acid.Among them 1--5-(m-benzyloxy)benzylbarbituric acid (37, BBBA) is the most promising having a Ki value of 1.1 +/- 0.2 nM wit

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