152167-85-6

Basic information

• Product Name: 5-Fluoro-8-Nitro Quinoline
• Synonyms: 5-Fluoro-8-Nitro Quinoline;Quinoline, 5-fluoro-8-nitro-
• CAS NO: 152167-85-6
• Molecular Formula: C9H5FN2O2
• Molecular Weight: 192.1466032
• Mol File: 152167-85-6.mol

Chemical Properties

• Boiling Point: 329.7 °C at 760 mmHg
• Flash Point: 153.2 °C
• Appearance: /
• Density: 1.446 g/cm³
• Vapor Pressure: 0.000335mmHg at 25°C
• Refractive Index: 1.654
• PKA: 0.22±0.29(Predicted)
• CAS DataBase Reference: 5-Fluoro-8-Nitro Quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-8-Nitro Quinoline(152167-85-6)
• EPA Substance Registry System: 5-Fluoro-8-Nitro Quinoline(152167-85-6)

Safety Data

• Hazardous Substances Data: 152167-85-6(Hazardous Substances Data)

Usage

Uses

5-Fluoro-8-nitroquinoline can be used to treat iron metabolic disorders.

InChI:InChI=1/C9H5FN2O2/c10-7-3-4-8(12(13)14)9-6(7)2-1-5-11-9/h1-5H

Upstream product

• 394-69-4 5-fluoroquinoline 
• 611-34-7 5-Aminoquinoline 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 2369-11-1 5-fluoro-2-nitroaniline 

Downstream Products

• 161038-18-2 8-amino-5-fluoroquinoline 

Relevant articles and documents

Synthesis of fluorine-containing 1,10-phenanthrolines using mild versions of Skraup and Doebner-von Miller reactions

A versatile route for the synthesis of new 1,10-phenanthroline derivatives with fluorine-containing groups is described. Skraup reactions were performed with yields of 19 up to 48% and overall yields of 5 up to 13% based on different fluorinated anilines as starting materials. Ten formerly unknown derivatives were synthesized and characterized by NMR spectroscopy (1H,13C,19F), ESI mass spectrometry and elemental analysis.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

Dual stimulatory and inhibitory effects of fluorine-substitution on mutagenicity: An extension of the enamine epoxide theory for activation of the quinoline nucleus

Nineteen mono- and di-fluorinated derivatives of quinoline, 1,7- phenanthroline, 1,10-phenanthroline, benzo-[h]quinoline, and benzo[f]quinoline were subjected to analysis of their structure-mutagenicity relationships. For this purpose, six new fluorinated derivatives were synthesized. The results support that the enamine epoxide structure of the pyridine moiety, as well as the bay-region epoxide structure, is responsible for mutagenicity. Formation of K-region epoxides might involve a detoxification process rather than mutagenic activation.