Anticancer activity of dihydropyrazolo[1,5-c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II
The design and synthesis of dihydropyrazolo[1,5-c]quinazolines (1a–h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the C6 rat glial cell line. Two compou
Synthesis and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives
Some 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives were rationally designed, synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Some notions about structure activity relationships are presented. Th
Synthesis, characterization and in vitro antifungal evaluation of tetrahydropyrazolo[1,5-c]quinazolines
The synthesis of a series of new pyrazolo[1,5-c]quinazolines starting from 2-nitrobenzaldehyde is described. The structures of the obtained compounds were established by NMR and X-ray diffraction. In contrast with other quinazoline derivatives, these comp
Insuasty, Braulio,Torres, Harlem,Quiroga, Jairo,Abonia, Rodrigo,Nogueras, Manuel,Sanchez, Adolfo,Sortino, Maximiliano,Zacchino, Susana,Low, John
p. 153 - 160
(2007/10/03)
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