- Synthetic method for 4-bromo-5-thiazolecarboxylic acid ethyl ester
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The invention belongs to the technical field of pharmaceutical intermediates, and relates to a synthetic method for 4-bromo-5-thiazolecarboxylic acid ethyl ester. The method comprises the following steps: mixing copper bromide, acetonitrile and isoamyl nitrite, performing heating to 60 DEG C, adding ethyl 4-aminothiazole-5-carboxylate in batches, after addition is completed, performing a reactionfor 30 min, after the raw materials are completely reacted, cooling the reaction solution to a room temperature, adding the cooled solution into hydrobromic acid, performing extraction by using ethylacetate, washing the organic phase by using water, performing drying by using anhydrous sodium sulfate, performing concentration, and performing treatment by using a chromatographic column to obtain the 4-bromo-5-thiazolecarboxylic acid ethyl ester. The method provided by the invention has low costs of the raw materials and a high yield, and is suitable for scale-up production.
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Paragraph 0019; 0026-0027
(2019/10/29)
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