Synthesis and structure - Activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands
A previous paper reported the synthesis of melatonin receptor ligands. In order to complete the structure-activity relationships and to obtain antagonists to the melatonin receptor, a new series of naphthalenic analogues of melatonin have been synthesized
Leclerc, Veronique,Fourmaintraux, Eric,Depreux, Patrick,Lesieur, Daniel,Morgan, Peter,Howell, H. Edward,Renard, Pierre,Caignard, Daniel-Henri,Pfeiffer, Bruno,Delagrange, Philippe,Guardiola-Lemaitre, Beatrice,Andrieux, Jean
The invention relates to a compound selected from those of general formula (I): STR1 in which R, R 1, R 2 and R 3 are as defined in the specification, an optical isomer, and an addition salt thereof with a pharmaceutically-acceptable base. Medicinal
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(2008/06/13)
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