- HETEROCYCLIC COMPOUNDS AS HIV PROTEASE INHIBITORS
-
The present invention is directed to compounds of Formula (I), pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
- -
-
Page/Page column 36-37
(2018/06/30)
-
- Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation
-
(Chemical Equation Presented) Reducing the electron density of ligands switches the regioselectivity of Rh(I)-catalyzed hydrometalation. A reversal of the sense of chiral induction was also observed when chiral ligands are electronically tuned in the same
- Wu, Hai-Chen,Hamid, Shafida Abd,Yu, Jin-Quan,Spencer, Jonathan B.
-
supporting information; experimental part
p. 9604 - 9605
(2011/03/19)
-
- N-methoxy-N-acylnitrenium ions: application to the formal synthesis of (-)-TAN1251A.
-
[structure: see text]. A formal synthesis of the muscarinic M(1) receptor antagonist (-)-TAN1251A (7) from L-tyrosine is described. Central to this venture has been the construction of the 1-azaspiro[4.5]decane skeleton present in the natural product by a
- Wardrop,Basak
-
p. 1053 - 1056
(2007/10/03)
-
- Ethanolamine derivatives having sympathomimetic and anti-pollakiuria activities
-
This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by the general formula [I]: STR1 wherein R1 is aryl or a heterocyclic group, each of which may be substituted with halogen, etc., R2 is hydrogen, halogen, nitro, hydroxy, lower alkyl optionally substituted with acyl, lower alkenyl optionally substituted with acyl, lower alkoxy optionally substituted with acyl, or amino optionally substituted with acyl(lower)alkyl, R3 is hydrogen, an N-protective group, or lower alkyl optionally substituted with lower alkylthio, n is an integer of 0 to 3, and a heavy solid line means a single bond or a double bond, provided that when n is 1, then 1) R1 is a condensed aromatic hydrocarbon group or a heterocyclic group, each of which may be substituted with halogen, etc., and the like, and pharmaceutically acceptable salts thereof to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
- -
-
-