152628-27-8Relevant articles and documents
Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication
Slater, Martin J.,Baxter, Robert,Bonser, Robert W.,Cockerill, Stuart,Gohil, Kam,Parry, Nigel,Robinson,Randall, Roger,Yeates, Clive,Snowden, Wendy,Walters, Adeline
, p. 1993 - 1995 (2001)
The synthesis and antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole nitrogen, is described. Structure-activity relationships in this series against human cytomegalovirus (HCMV) replication in cell culture are reported. Compound 4b was identified as potent inhibitor of HCMV (IC50=19 nM), which retained activity against a range of HCMV strains including ganciclovir resistant isolates.
Bisindolyl maleimide derivative and preparation method and application thereof
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Paragraph 0463; 0464; 0571; 0572, (2017/01/02)
The invention provides a bisindolyl maleimide derivative and a preparation method and application thereof. The bisindolyl maleimide derivative has an excellent alpha-glucosidase inhibition effect and can be used for preventing and treating diabetes.
Bisindolylmaleimide derivative, and preparation method and use thereof
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Paragraph 0466; 0467, (2017/04/03)
The invention provides a bisindolylmaleimide derivative, and a preparation method and a use thereof. The bisindolylmaleimide derivative has a good tumor treatment effect, especially has a good treatment effect on some drug-resistant tumors, and can realize accurate treatment of the drug-resistant tumors.