Intramolecular Amidoalkylation of Chiral Iminium Ions: Stereoselective Synthesis of syn-1,3-Aminoalcohols
The intramolecular Hosomi-Sakurai reaction of 3-siloxybutaniminium salts exhibited a syn selectivity of up to 51:1, while the same type of reaction of 2-methyl-3-siloxypropaniminium salts showed up to 290:1 syn selectivity.