152673-32-0 Usage
Uses
Used in Organic Synthesis:
1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S-trans)-(9CI) is used as a building block in organic synthesis for the creation of complex organic molecules. Its unique structure and reactivity make it a valuable component in the synthesis of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Production:
In the pharmaceutical industry, L-proline tert-butyl ester is utilized as a key intermediate in the synthesis of drugs. Its ability to enhance the stability and bioactivity of peptides and proteins makes it an essential component in the development of new therapeutic agents.
Used in Asymmetric Synthesis:
As a chiral auxiliary, 1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S-trans)-(9CI) is employed in asymmetric synthesis to control the stereochemistry of reactions, leading to the production of enantiomerically pure compounds. This is crucial for the development of drugs with specific biological activities and reduced side effects.
Used in Peptide and Protein Modification:
L-proline tert-butyl ester is used as a modifying agent in the field of biochemistry to improve the stability and bioactivity of peptides and proteins. Its incorporation into these biomolecules can lead to enhanced therapeutic properties and applications in research and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 152673-32-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,6,7 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 152673-32:
(8*1)+(7*5)+(6*2)+(5*6)+(4*7)+(3*3)+(2*3)+(1*2)=130
130 % 10 = 0
So 152673-32-0 is a valid CAS Registry Number.
152673-32-0Relevant articles and documents
Chiral quinolone intermediates
-
, (2008/06/13)
Chiral compounds having the formulae STR1 useful in the synthesis of quinolone intermediates.
Design, Synthesis, and Properties of (4S)-7-(4-Amino-2-substituted-pyrrolidin-1-yl)quinolone-3-carboxylic Acids
Rosen, Terry,Chu, Daniel T. W.,Lico, Isabella M.,Fernandes, Prabhavathi B.,Marsh, Kennan,et al.
, p. 1598 - 1611 (2007/10/02)
The quinolinecarboxylic acids constitute a class of extremely potent and orally active broad-spectrum antibacterial agents.These compounds have been shown to inhibit DNA gyrase, a key enzyme in bacterial DNA replication.The 7-(3-aminopyrrolidinyl)quinolone A-60969 (1) is a particularly potent member of this class and is currently undergoing clinical evaluation.We have studied a series of enantiomerically homogeneous (4S)-7-(4-amino-2-substituted-pyrrolidinyl)quinolones in an effort to utilize the 2-position of the pyrrolidine moiety to improve upon the solubility and pharmacokinetic properties of this class of compounds while still maintaining potent antibacterial activity.We have found that the absolute stereochemistry at the 2-position of the pyrrolydine ring is critical to the maintenance of such activity.In this paper, we report the full details of the asymmetric synthesis and the in vitro and in vivo structure-activity relationships of this series of compounds as well as the physiochemical properties, such as water solubility and log P, associated with the structural modifications.We also discuss the pharmacokinetic properties of several of these compounds in mice and the pharmacokinetics of 59, which has the best overall properties of agents in this study, in dog.
