152699-63-3

Basic information

• Product Name: DIBENZYL 5-AMINOISOPHTHALATE
• Synonyms: DIBENZYL 5-AMINOISOPHTHALATE;5-Aminobenzene-1,3-dicarboxylic acid dibenzyl ester~5-Aminoisophthalic acid dibenzyl ester;5-Aminoisophthalic acid dibenzyl ester~Dibenzyl 5-aminobenzene-1,3-dicarboxylate;5-Aminoisophthalicaciddibenzylester;5-aminobenzene-1,3-dicarboxylic acid dibenzyl ester;5-aminobenzene-1,3-dicarboxylic acid dibenzyl e
• CAS NO: 152699-63-3
• Molecular Formula: C₂₂H₁₉NO₄
• Molecular Weight: 361.39
• Mol File: 152699-63-3.mol

Chemical Properties

• Melting Point: 116-118°C
• Boiling Point: 561.3°Cat760mmHg
• Flash Point: 233.1°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 1.26E-12mmHg at 25°C
• Refractive Index: 1.631
• PKA: 2.21±0.10(Predicted)
• BRN: 744276
• CAS DataBase Reference: DIBENZYL 5-AMINOISOPHTHALATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIBENZYL 5-AMINOISOPHTHALATE(152699-63-3)
• EPA Substance Registry System: DIBENZYL 5-AMINOISOPHTHALATE(152699-63-3)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 152699-63-3(Hazardous Substances Data)

Usage

Uses

Used in Polymer Synthesis:
DIBENZYL 5-AMINOISOPHTHALATE is used as a monomer for the production of high-performance polymers due to its heat, chemical, and abrasion resistance, which enhances the durability and performance of the resulting polymers.
Used in Adhesives Industry:
In the adhesives industry, DIBENZYL 5-AMINOISOPHTHALATE is used as a component to improve the thermal and mechanical properties of adhesive formulations, ensuring strong bonds and resistance to environmental factors.
Used in Coatings Industry:
DIBENZYL 5-AMINOISOPHTHALATE is utilized as a key ingredient in the development of high-quality coatings, providing excellent adhesion, durability, and resistance to various environmental stresses, including heat and chemicals.
Used in Electronic Materials Industry:
This chemical compound is employed in the manufacturing of electronic materials, where its thermal stability and mechanical strength are crucial for the performance and reliability of electronic devices and components.
Used in Specialty Chemicals and Pharmaceuticals Production:
DIBENZYL 5-AMINOISOPHTHALATE also serves as a component in the production of specialty chemicals and pharmaceuticals, where its unique properties contribute to the development of innovative and effective products.

InChI:InChI=1/C22H19NO4/c23-20-12-18(21(24)26-14-16-7-3-1-4-8-16)11-19(13-20)22(25)27-15-17-9-5-2-6-10-17/h1-13H,14-15,23H2

Upstream product

• 167993-08-0 5-Nitro-isophthalic acid dibenzyl ester 

Downstream Products

• 174604-08-1 N-tert-butyloxycarbonyl-1S-(3,5-dibenzyloxycarbonylphenylamino-carbonyl)-2-phenylethylamine 
• 178896-43-0 5-[(S)-2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionylamino]-isophthalic acid dibenzyl ester 
• 494847-53-9 5-[(2-tert-Butoxycarbonyl-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-isophthalic acid dibenzyl ester 
• 494847-54-0 5-[(3-tert-Butoxycarbonyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-2-carbonyl)-amino]-isophthalic acid dibenzyl ester 
• 494847-55-1 5-[(3-tert-Butoxycarbonyl-1,2,3,4,5,6-hexahydro-benzo[d]azocine-2-carbonyl)-amino]-isophthalic acid dibenzyl ester 
• 494847-56-2 5-[(3-tert-Butoxycarbonyl-2,3,4,5,6,7-hexahydro-1H-benzo[d]azonine-2-carbonyl)-amino]-isophthalic acid dibenzyl ester 
• 494847-57-3 2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-N-(tert-butoxycarbonyl)-1,2,3,4,5,6,7,8-octahydro-3-benzazecine 
• 869584-11-2 5-[(2-cycloheptylmethyl-5-phenyl-1H-pyrrole-3-carbonyl)-amino]-isophthalic acid dibenzyl ester 
• 1025804-79-8 5-[(5-cycloheptylmethyl-2-phenyl-1H-imidazole-4-carbonyl)-amino]-isophthalic acid dibenzyl ester 
• 372489-01-5 5-((2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carbonyl)amino)isophthalic acid dibenzyl ester 
• 869584-12-3 5-{[2-(2-adamantan-1-yl-ethyl)-5-phenyl-1H-pyrrole-3-carbonyl]-amino}-isophthalic acid dibenzyl ester 
• 869584-13-4 5-[(2-cycloheptylmethyl-5-naphthalen-2-yl-1H-pyrrole-3-carbonyl)-amino]-isophthalic acid dibenzyl ester 
• 269070-88-4 5-((5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)amino)isophthalic acid dibenzyl ester 

Relevant articles and documents

Isophthalic acid derivatives as matrix metalloproteinase inhibitors

Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; each R4 and R5 independently are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring, optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.

CCK AND GASTRIN RECEPTOR LIGANDS

Compounds of formula (I) and their pharmaceutically active salts are gastrin and CCK receptor ligands, where Ar is a monocyclic aromatic group, R 1 is halo, amino, nitro, cyano, sulphamoyl, sulphonyl, trifluoromethyl, C 1 to C 3 alkyl, C 1 to C 3 alkylamino, C 1 to C 3 dialkylamino, phenyl, substituted phenyl, C 1 to C. sub.3 alkoxy, hydroxy, esterified hydroxy, C 1 to C 3 hydroxyalkyl, C 1 to C 3 alkylcarboxyamino, carboxy, esterified carboxy and amidated carboxy, m is 0, 1, 2, 3, or 4, provided that m is not more than 2 unless R 1 is exclusively halo, x+y=0 or 1, R 2 and R 4 independently are II, or C 1 to C 3 alkyl, R 3 is H or C 1 to C 15 hydrocarbyl, where one or more hydrogen atoms of die hydrocarbyl group may be replaced by a halogen atom, and where up to two of the carbon atoms may be replaced by a nitrogen, oxygen or sulphur atom, provided that R 3 does not contain a--O--O--group, R 5 is H or C 1 to C 3 alkyl, U is a cyclic moiety, selected from the group consisting of aryl, aromatic heterocyclic, non-aromatic heterocyclic, and cycloalkyl groups, where the aryl or aromatic group contains up to 3 substituents selected from the group consisting of halo, amino, nitro, cyano, sulphamoyl, sulphonyl, trifluoromethyl, C. sub.1 to C 3 alkyl, C 1 to C 3 alkylamino, C 1 to C 3 dialkylamino, phenyl, C 1 to C 3 alkoxy, hydroxy, esterified hydroxy, C 1 to C 3 hydroxyalkyl, C 1 to C 3 alkylcarboxyamino, carboxy, esterified carboxy and amidated carboxy, Z is a group of the formula (IIa) or (IIb) where R. sup.6 is H or C 1 to C. sub.3 alkyl, X is--CO 2 H, esterified carboxy, amidated carboxy, tetrazolyl, hydroxy, cyano, amidino,--CH 2 OH,--SO 2 NHCOR 7,--SONHCOR 7,--COR 7,--NHSO 2 R 7,--CONHSO 2 R. sup.7,--NHCOR 7 or--SO 2 NHR 8, where R. sup. 7 is C 1 to C 6, alkyl, C 1 to C 6 aryl or substituted aryl, and R 8 is--OH,--CN, C 1 to C 6 alkyl, C 1 to C. sub.6 haloalkyl, aryl or substituted aryl, Y is H or a group selected from those recited above for X, and a is 0, 1, or 2. STR1

GASTIN AND CCK RECEPTOR LIGANDS

Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R 1 (m) represents up to 6 substituents, K represents--O--,--S--,--CH 2--,--N(R 2)--or--N(COR 2)--, in which R 2 is H or C 1 to C 3 alkyl, W is a carbonyl, sulfonyl or sulfinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description, and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors. STR1

BICYCLO[2,2,2]OCTANE DERIVATIVES

The compounds of the formula I STR1 and their pharmaceutical acceptable salts, which are defined herein, are ligands for cholecystokinin and/or gastrin receptors.