153037-40-2

Basic information

• Product Name: 1426129-50-1 enantioMer
• Synonyms: 1426129-50-1 enantioMer;(S)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbaMate;(2S)-2-(tert-Butoxycarbonylamino)-3-(biphenyl-4-yl)propanol;Carbamic acid, N-[(1S)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 153037-40-2
• Molecular Formula: C₂₀H₂₅NO₃
• Molecular Weight: 327.4174
• EINECS: -0
• Mol File: 153037-40-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1426129-50-1 enantioMer(CAS DataBase Reference)
• NIST Chemistry Reference: 1426129-50-1 enantioMer(153037-40-2)
• EPA Substance Registry System: 1426129-50-1 enantioMer(153037-40-2)

Safety Data

• Hazardous Substances Data: 153037-40-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1426129-50-1 enantioMer is used as a chiral building block for the synthesis of chiral molecules and drugs. Its distinct enantiomeric form plays a vital role in understanding its properties and potential applications in drug development, ensuring the creation of effective and safe medications.
Used in Drug Development Research:
In the field of drug development research, 1426129-50-1 enantioMer is utilized to study the different biological activities and pharmacological properties of enantiomers. This research is essential for optimizing drug efficacy and minimizing potential side effects, ultimately leading to the discovery of novel therapeutic agents.
Used in Chemistry:
1426129-50-1 enantioMer also finds applications in various chemical processes due to its unique molecular structure. It can be employed as a catalyst or reagent in asymmetric synthesis, contributing to the production of enantiomerically pure compounds with specific biological activities.

Upstream product

• 109-02-4 4-methyl-morpholine 
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• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

A kind of the heart fades the medicine Entresto key intermediate (R)- tert-butyl (1 - ([1, 1' - biphenyl] - 4 - yl) - 3 - hydroxy - 2 - yl) carbamate preparation method

The invention relates to a preparation method of a drug key intermediate, particularly a method for preparing (R)-tert-butyl-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropane-2-yl)carbamate by chiral resolution. The method has the advantages of cheap and accessible raw materials, low production cost, high separation yield and high chiral purity of the product, and is simple to operate, friendly to the environment and suitable for industrial production.

New thiazole carboxamides as potent inhibitors of Akt kinases

A new series of 2-substituted thiazole carboxamides were identified as potent pan inhibitors against all three isoforms of Akt (Akt1, Akt2 and Akt3) by systematic optimization of weak screening hit N-(1-amino-3-phenylpropan-2-yl)- 2-phenylthiazole-5-carboxamide (1). One of the most potent compounds, 5m, inhibited the kinase activities of Akt1, Akt2 and Akt3 with IC50 values of 25, 196 and 24 nM, respectively. The compound also potently inhibited the phosphorylation of downstream MDM2 and GSK3β proteins, and displayed strongly antiproliferative activity in prostate cancer cells. The inhibitors might serve as lead compounds for further development of novel effective anticancer agents.

PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES AS ECE INHIBITORS

The present invention relates to the N-phosphonomethyl substituted compounds of formula STR1

PHOSPHONO/BIARYL SUBSTITUTED AMINO ACID DERIVATIVES

The present invention relates to the N-phosphonomethyl-biaryl substituted amino acid derivatives of formula I STR1 wherein X represents a direct bond, C 1-4-alkylene or C 2-C 4-alkenylene; R and R' represent independently hydrogen, carbocyclic aryl, 6-tet