153334-38-4

Basic information

• Product Name: Ethanone, 1-(1-methyl-1H-1,2,4-triazol-3-yl)- (9CI)
• Synonyms: Ethanone, 1-(1-methyl-1H-1,2,4-triazol-3-yl)- (9CI);1-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)ETHANONE
• CAS NO: 153334-38-4
• Molecular Formula: C5H7N3O
• Molecular Weight: 125.12858
• Product Categories: ACETYLGROUP
• Mol File: 153334-38-4.mol

Chemical Properties

• Boiling Point: 267.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 0.48±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(1-methyl-1H-1,2,4-triazol-3-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(1-methyl-1H-1,2,4-triazol-3-yl)- (9CI)(153334-38-4)
• EPA Substance Registry System: Ethanone, 1-(1-methyl-1H-1,2,4-triazol-3-yl)- (9CI)(153334-38-4)

Safety Data

• Hazardous Substances Data: 153334-38-4(Hazardous Substances Data)

Upstream product

• 153334-29-3 3-acetyl-1H-1,2,4-triazole 
• 74-88-4 methyl iodide 

Relevant articles and documents

6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR

The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

Synthesis and application of triazole derivatives. Synthesis of 3- and 5- acyl-1,2,4-triazoles via lithiation of 1-alkyl-1H-1,2,4-triazoles

N-Unsubstituted 3-acyl-1H-1,2,4-triazoles (3), and 5-acyl-1-alkyl-1H- 1,2,4-triazoles (4) were synthesized by acylation of 5-lithiotriazoles with amides. The 3-position of l-methyl-5-phenylthio-1H-1,2,4-triazole (11) was lithiated by lithium 2,2,6,6-tetra