- Preparation of labeled human drugmetabolites and drug-drug interaction-probes with fungal peroxygenases
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Enzymatic conversion of a drug can be an efficient alternative for the preparation of a complex metabolite compared with a multi-step chemical synthesis approach. Limitations exist for chemical methods for direct oxygen incorporation into organic molecule
- Poraj-Kobielska, Marzena,Atzrodt, Jens,Holla, Wolfgang,Sandvoss, Martin,Groebe, Glenn,Scheibner, Katrin,Hofrichter, Martin
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p. 513 - 519
(2014/03/21)
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- Synthesis of stable isotope labelled internal standards for drug-drug interaction (DDI) studies
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The syntheses of stable isotope labelled internal standards of important CYP-isoform selective probes, like testosterone 1, diclofenac 3, midazolam 5, and dextromethorphan 7, as well as their corresponding hydroxylated metabolites 6β-hydroxytestosterone 2
- Atzrodt,Blankenstein,Brasseur,Calvo-Vicente,Denoux,Derdau,Lavisse,Perard,Roy,Sandvoss,Schofield,Zimmermann
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p. 5658 - 5667
(2012/10/30)
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- Synthesis of deuterium labelled diclofenac with improved isotopic enrichment
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A five-step synthesis of deuterium-labelled diclofenac starting from 2-phenyl[2H5] acetic acid is described. The synthesis prevents deuterium from scrambling during the reaction. It offers the labelled compound with over 99% isotopic
- Keying, Wu,Lei, Tian,Hongye, Li,Jian, Li,Liqin, Chen
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experimental part
p. 535 - 537
(2010/07/02)
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- Synthesis of deuterium-labelled diclofenac sodium
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Diclofenac sodium labelled with deuterium in the phenylacetic ring was prepared from [2H5]-bromobenzene in a six-step reaction. It was found to be suitable for use in pharmacokinetic and bioavailability studies in man.
- Leroy,Richard,Godbillon
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p. 1019 - 1027
(2007/10/02)
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