153804-50-3Relevant articles and documents
Substituted oxygenated heterocycles and thio-analogues: Synthesis and biological evaluation as melatonin ligands
Charton, Isabelle,Mamai, Ahmed,Bennejean, Caroline,Renard, Pierre,Howell, Edward H.,Guardiola-Lemaitre, B.Eatrice,Delagrange, Philippe,Morgan, Peter J.,Viaud, Marie-Claude,Guillaumet, G.Erald
, p. 105 - 114 (2007/10/03)
A new series of substituted oxygenated heterocycles and thio-analogues were synthesized and evaluated as melatonin receptor ligands. The replacement of the indolic moiety of melatonin by heterocyclic skeleton such as 1,4- benzodioxin, 2,3-dihydro-1,4-benzodioxin, chroman, 2,3-dihydro-1,4- benzoxathiin, thiochroman, carrying the amidic chain on the aromatic ring, leads to compounds showing a weak affinity for melatonin receptors, except for the compounds 1cb and 1hb. (C) 2000 Elsevier Science Ltd.
THIOCHROMAN COMPOUNDS
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, (2008/06/13)
The invention relates to compounds of the formula I: STR1 in which R 1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, andmedicinal products which are useful for treating Central Nervous System disorders.