154078-95-2Relevant articles and documents
A New General Method To Obtain Chiral 2-Alkylglycidyl Acid Derivatives: Synthesis of Methyl (R)-(+)-Palmoxirate
Garcia Ruano, Jose L.,Martin Castro, Ana M.,Rodriguez, Jesus H.
, p. 533 - 536 (2007/10/02)
The hydrolysis of the diastereomerically pure cyanohydrins, obtained by reaction of Et2AlCN with homochiral α-sulfinyl ketones, yielded β-sulfenyl esters or amides, which evolved into the corresponding 2-alkylglycidic acid derivatives (ee >97percent) by treatment with Me3O(1+)BF4(1-) and NaHCO3.The use of this sequence to synthesize optically pure (R)-(+)-palmoxirate, a powerful hypoglicemic agent, is also described.