cas 154212-56-3, cosalane | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
154212-56-3

Articles about 154212-56-3Total 1 be found

Article title
Article abstract
Author
Journal number and time
Download

Design, Synthesis, and Biological Evaluation of Cosalane, a Novel Anti-HIV Agent Which Inhibits Multiple Features of Virus Reproduction
Cosalane (3), a novel anti-HIV agent having a disalicylmethane unit linked to C-3 of cholestane by a three-carbon linker, was synthesized from commercially available starting materials by a convergent route.Cosalane proved to be a potent inhibitor of HIV with a broad range of activity against a variety of laboratory, drug-resistant, and clinical HIV-1 isolates, HIV-2, and Rauscher murine leukemia virus.The cytotoxicity of cosalane is relatively low as reflected by an in vitro therapeutic index of > 100.Although cosalane inhibits HIV-1 reverse transcriptase and protease, time of addition experiments indicate that it prevents the cytopathic effect of HIV by acting earlier than reverse transcription in the viral replication cycle.The available evidence indicates that the primary mechanism of action of cosalane involves inhibition of gp 120-CD4 binding as well as inhibition of a postattachment event prior to reverse transcription.
Cushman, Mark,Golebiewski, W. Marek,McMahon, James B.,Buckheit, Robert W.,Clanton, David J.,et al.
p. 3040 - 3050
(2007/10/02)

More Articles about upstream products of 154212-56-3

More Articles about downstream products of 154212-56-3

Chemical Properties

Boiling Point: 797.4°Cat760mmHg
Flash Point:436.1°C
Density: 1.191g/cm³
Vapor Pressure: 7.99E-27mmHg at 25°C
PSA: 115.06000
LogP: 12.75040

Show more

Global suppliers and manufacturers of 154212-56-3total 6 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Henan Wentao Chemical Product Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:44
Country:

Zibo Hangyu Biotechnology Development Co., Ltd
Business Type:Lab/Research institutions
Min Order:10 Gram
FOB Price:No Data
Main Products:313
Country:

Xi`an Eastling Biotech Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:21
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

Shanghai Chinqesen Biotechnology Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:79
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:27
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 154212-56-3

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer