Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent
We report the discovery, synthesis, and biological activities of phenoxy-4-pyrone and phenoxy-4-pyridone derivatives as novel inhibitors of enoyl-acyl carrier protein reductase (FabI). Pyridone derivatives showed better activities than pyrone derivatives
Kim, Yun Gyeong,Seo, Jae Hong,Kwak, Jin Hwan,Shin, Kye Jung
p. 4481 - 4486
(2015/10/12)
Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds
A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented.
N-SULPHONYLAMINOACETONITRILES HAVING PESTICIDAL PROPERTIES
The invention relates to compounds of the general formula (I) and, if appropriate, enantiomers thereof. The active compounds have advantageous pesticidal properties. They are suitable, in particular, for the control of parasites in warm-blooded animals.
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Page 26
(2008/06/13)
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