154747-82-7

Basic information

• Product Name: (R)-1-(CHLOROMETHYL)-5-METHYL-2-PYRROLIDINONE
• Synonyms: (R)-1-(CHLOROMETHYL)-5-METHYL-2-PYRROLIDINONE;(5R)-1-(chloroMethyl)-5-Methyl-2-Pyrrolidinone
• CAS NO: 154747-82-7
• Molecular Formula: C₆H₁₀ClNO
• Molecular Weight: 147.6
• Mol File: 154747-82-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-1-(CHLOROMETHYL)-5-METHYL-2-PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(CHLOROMETHYL)-5-METHYL-2-PYRROLIDINONE(154747-82-7)
• EPA Substance Registry System: (R)-1-(CHLOROMETHYL)-5-METHYL-2-PYRROLIDINONE(154747-82-7)

Safety Data

• Hazardous Substances Data: 154747-82-7(Hazardous Substances Data)

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 

Relevant articles and documents

5(R)-Methyl-1-(chloromethyl)-2-pyrrolidinone: A New Reagent for the Determination of Enantiomeric Composition of Alcohols

We have prepared a new chiral nonracemic reagent (5(R)-methyl-1-(chloromethyl)-2-pyrrolidinone) in enantiopure form that reacts with alcohols containing a stereogenic center to produce diastereomeric N-(alkoxymethyl)-2-pyrrolidinone derivatives.These derivatives exhibit large and easily observed diastereotopic signals in the proton NMR that allow direct determination of diastereomeric ratio (percent dr) for the product.

An optimised synthetic approach to a chiral derivatising agent and the utilisation of a dimerisation reaction in the synthesis of a novel C2-symmetric diphosphine ligand

We report an optimised synthetic approach to the chiral derivatising agent (5R)-methyl-1-(chloromethyl)-2-pyrrolidinone. In addition, the observation of an unwanted dimerisation product is turned to our advantage by providing a method for the synthesis of a new class of C2-symmetric chiral diphosphine.