154807-47-3

Basic information

• Product Name: 4-Isothiazolecarbonylchloride, 5-amino-3-methyl-
• Synonyms: 4-Isothiazolecarbonyl chloride, 5-amino-3-methyl- (9CI)
• CAS NO: 154807-47-3
• Molecular Formula: C₅H₅ClN₂OS
• Molecular Weight: 176.624
• Product Categories: ACIDHALIDE
• Mol File: 154807-47-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Isothiazolecarbonylchloride, 5-amino-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isothiazolecarbonylchloride, 5-amino-3-methyl-(154807-47-3)
• EPA Substance Registry System: 4-Isothiazolecarbonylchloride, 5-amino-3-methyl-(154807-47-3)

Safety Data

• Hazardous Substances Data: 154807-47-3(Hazardous Substances Data)

Upstream product

• 22131-51-7 5-amino-3-methyl-1,2-thiazole-4-carboxylic acid 

Relevant articles and documents

AMINO-SUBSTITUTED ISOTHIAZOLES

The present invention relates to amino-substituted isothiazoles of general formula (I): in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

AMINO-SUBSTITUTED ISOTHIAZOLES

The present invention relates to amino-substituted isothiazoles of general formula (I) : in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

New amides of 5-acylamino-3-methyl-4-isothiazolecarboxylic acid and their immunotropic activity

Several new amides 4 of 5-substituted 3-methyl-4-isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino-acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo.

Synthesis of isothiazole derivatives with potential biological activity

The synthesis of acyl and ureido derivatives of substituted amides of 3-methyl-5-aminoisothiazole-4-carboxylic acid is presented. The structures of the compounds obtained were established on the basis of IR, 1H NMR and elemental analysis. The influence on the circulatory system of the derivatives was investigated.