154848-38-1

Basic information

• Product Name: 3-(3-Methoxyphenyl)benzonitrile
• Synonyms: 3-(3-Methoxyphenyl)benzonitrile
• CAS NO: 154848-38-1
• Molecular Formula: C14H11NO
• Molecular Weight: 209.24324
• Mol File: 154848-38-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(3-Methoxyphenyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-Methoxyphenyl)benzonitrile(154848-38-1)
• EPA Substance Registry System: 3-(3-Methoxyphenyl)benzonitrile(154848-38-1)

Safety Data

• Hazardous Substances Data: 154848-38-1(Hazardous Substances Data)

Upstream product

• 6952-59-6 3-cyanobromobenzene 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 10365-98-7 3-methoxyphenylboronic acid 

Downstream Products

• 1436712-38-7 (3'-methoxybiphenyl-3-yl)(pyridin-4-yl)methanimine 
• 1436712-41-2 2-(3'-methoxybiphenyl-3-yl)-2-(pyridin-4-yl)thiazolidin-4-one 
• 1436712-44-5 C₂₁H₁₉N₃OS 

Relevant articles and documents

Pd/REOs catalysts applied to the Suzuki-Miyaura coupling. A comparison of their catalytic performance and reusability

Two new palladium catalysts based on rare earth oxide supports, namely, Pd/Dy2O3 and Pd/Yb2O3 were prepared by the incipient wetness impregnation method, followed by calcination at 600 °C. Both compounds, which were fully characterized, were tested as catalysts in the Suzuki-Miyaura reaction and their catalytic activity was compared with that of already known Pd/La2O3, Pd/CeO2, Pd/Pr6O11, Pd/Sm2O3, and Pd/Gd2O3. It has been found that the nature of the support strongly affects the catalytic activity. The scope of the catalytic protocol was investigated and quantitative yields of the coupling products (21 examples are reported) were always observed using a low metal amount (0.05 mol%). A systematic investigation on the reusability of the entire set of catalytic systems has been carried out. All catalysts showed to be successfully recyclable, and also in this case the nature of the rare earth element is crucial. The highest reusability was observed for catalysts Pd/CeO2 and Pd/Sm2O3.

Efficient phosphine ligands for the one-pot palladium-catalyzed borylation/Suzuki-Miyaura cross-coupling reaction

We report the synthesis of 2-(anthracen-9-yl)-1H-inden-3-yl dicyclohexylphosphine and its use in palladium-catalyzed borylation/Suzuki-Miyaura cross-coupling reaction to prepare a variety of symmetrical and unsymmetrical biaryl compounds in excellent yield. This journal is

Core refinement toward permeable β-secretase (BACE-1) inhibitors with low hERG activity

By use of iterative design aided by predictive models for target affinity, brain permeability, and hERG activity, novel and diverse compounds based on cyclic amidine and guanidine cores were synthesized with the goal of finding BACE-1 inhibitors as a treatment for Alzheimer's disease. Since synthesis feasibility had low priority in the design of the cores, an extensive synthesis effort was needed to make the relevant compounds. Syntheses of these compounds are reported, together with physicochemical properties and structure-activity relationships based on in vitro data. Four crystal structures of diverse amidines binding in the active site are deposited and discussed. Inhibitors of BACE-1 with 3 μM to 32 nM potencies in cells are shown, together with data on in vivo brain exposure levels for four compounds. The results presented show the importance of the core structure for the profile of the final compounds.

BIPHENYL DERIVATIVES

Novel compounds of the formula I in which X, R 1, R 2, R 3, R 4 and R 5 have the meaning indicated in Patent Claim 1, are inhibitors of the coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.