155043-84-8

Basic information

• Product Name: 4-[6,7-Diethoxy-2,3-bis(hydroxymethyl)naphthalen-1-yl]-1-(2-methoxyethyl)pyridin-2(1H)-one
• Synonyms: T-440
• CAS NO: 155043-84-8
• Molecular Formula: C₂₄H₂₉NO₆
• Molecular Weight: 427.4902
• Mol File: 155043-84-8.mol

Chemical Properties

• Boiling Point: 682.7°C at 760 mmHg
• Flash Point: 366.7°C
• Density: 1.235g/cm³
• Vapor Pressure: 1.41E-19mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 4-[6,7-Diethoxy-2,3-bis(hydroxymethyl)naphthalen-1-yl]-1-(2-methoxyethyl)pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[6,7-Diethoxy-2,3-bis(hydroxymethyl)naphthalen-1-yl]-1-(2-methoxyethyl)pyridin-2(1H)-one(155043-84-8)
• EPA Substance Registry System: 4-[6,7-Diethoxy-2,3-bis(hydroxymethyl)naphthalen-1-yl]-1-(2-methoxyethyl)pyridin-2(1H)-one(155043-84-8)

Safety Data

• Hazardous Substances Data: 155043-84-8(Hazardous Substances Data)

Upstream product

• 155044-57-8 6,7-diethoxy-1-[1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridin-4-yl]naphthalene-2,3-dicarboxylic acid dimethyl ester 
• 155044-45-4 6,7-Diethoxy-1-(2-oxo-1,2-dihydro-pyridin-4-yl)-naphthalene-2,3-dicarboxylic acid dimethyl ester 
• 155042-77-6 1-(pyridin-4-yl)-2,3-bis(methoxycarbonyl)-6,7-diethoxynaphthalene 
• 155044-36-3 1-(4-pyridyl)-2,3-bis(methoxycarbonyl)-6,7-diethoxynaphthalene N-oxide 

Relevant articles and documents

An efficient synthesis of the anti-asthmatic agent T-440: A selective N- alkylation of 2-pyridone

6,7-Diethoxy-1-[1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridin-4- yl]naphthalene-2,3-dimethanol [T-440, (1)] is a potential anti-asthmatic agent based on selective phosphodiesterase 4 inhibition. It was necessary for the further evaluation of 1 to develop an

TERTIARY AMINES, MEDICAMENTS CONTAINING SAID AMINES, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

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A series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans have been synthesized and evaluated for their ability to selectively inhibit PDE IV isolated from guinea pig. Replacement of the 1-phenyl ring by a pyridone ring led to marked improvement of the

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Naphthalene derivative of the formula [I]: STR1 wherein R1 and R2 are the same or different and are hydrogen atom, hydroxy group, cyclo-lower alkyloxy group, substituted or unsubstituted lower alkoxy group, or both combine each other to form lower alkylenedioxy group, R3 is substituted or unsubstituted nitrogen-containing 6-membered heterocyclic group, and groups of the formulae: --OR4 and --OR5 are the same or different and are protected or unprotected hydroxy group, processes for preparing thereof, and synthetic intermediates therefor, these compounds have excellent bronchodilating activity, and are useful in the prophylaxis and treatment of asthma.