155269-60-6

Basic information

• Product Name: 2-Pyridinemethanol,6-ethenyl-(9CI)
• Synonyms: 2-Pyridinemethanol,6-ethenyl-(9CI);(6-ethenylpyridin-2-yl)methanol
• CAS NO: 155269-60-6
• Molecular Formula: C8H9NO
• Molecular Weight: 135.16316
• Product Categories: PYRIDINE
• Mol File: 155269-60-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyridinemethanol,6-ethenyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinemethanol,6-ethenyl-(9CI)(155269-60-6)
• EPA Substance Registry System: 2-Pyridinemethanol,6-ethenyl-(9CI)(155269-60-6)

Safety Data

• Hazardous Substances Data: 155269-60-6(Hazardous Substances Data)

Upstream product

• 1058704-52-1 2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-6-ethenylpyridine 
• 33674-96-3 2-bromo-6-(hydroxymethyl)pyridine 
• 150058-63-2 2-bromo-6-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)pyridine 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 579500-16-6 6-vinylpinacolinaldehyde 

Downstream Products

• 1228957-88-7 C₂₆H₂₀Cl₂N₄O₃ 

Relevant articles and documents

Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCθ inhibitors

Analog 8, a 3-pyridinecarbonitrile with an (E)-2-{6-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}vinyl group at C-5, had an IC50 value of 1.1 nM for the inhibition of PKCθ and potently blocked the production of IL-2 in both stimulated murine T cells (IC50 = 34 nM) and human whole blood (IC50 = 500 nM).

PYRIDINE DERIVATIVE AND MEDICINE

The main purpose of the invention is to provide a novel pyridine derivative or a pharmaceutically acceptable salt thereof. Examples of the invention include a pyridine derivative represented by general formula [1], and a pharmaceutically acceptable salt thereof. This compound or a pharmaceutically acceptable salt thereof exhibits mGluR5 inhibitory activity, and can therefore be used as an agent for the prevention or treatment of, e.g., pain (for example, acute pain, chronic pain, inflammatory pain, neuropathic pain, hyperalgesia, thermal hyperalgesia, allodynia, pain due to noxious thermal stimulation, pain due to noxious mechanical stimulation, pain in the lower urinary tract or reproductive organs, or migraine), pruritus, lower urinary tract symptoms or lower urinary tract dysfunctions, gastroesophageal reflux disease (GERD), gastroesophageal reflux associated with transient lower esophageal sphincter relaxation (TLESR), and diseases of the central nervous system.

Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors

The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC50 values of 2.1 and 58 nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study.

5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS

Described herein are compounds of formula I: wherein G is and pharmaceutically acceptable salts thereof, wherein J, X, R1, R2, R11, R12' and p are as defined herein. Also provided herein are methods of making the compounds of formula I, and methods of using these compounds for inhibiting or treating a pathological condition or disorder linked to or mediated by a protein kinase in a mammal.

Branch-selective reductive coupling of 2-vinyl pyridines and imines via rhodium catalyzed C-C bond forming hydrogenation

Hydrogenation of 2-vinyl azines 1a-1e in the presence of N-arylsulfonyl imines 2a-2l at ambient temperature and pressure employing cationic rhodium catalysts ligated by tri-2-furylphosphine results in regioselective reductive coupling to furnish branched