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4-(2,4-Difluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one, commonly known as rufinamide, is a synthetic antiepileptic drug specifically designed to prevent seizures in patients with Lennox-Gastaut syndrome, a severe form of epilepsy. Rufinamide operates by modulating the activity of sodium channels in the brain, which aids in stabilizing the electrical activity of neurons and diminishing the likelihood of abnormal electrical impulses that can lead to seizures. This medication is administered orally and has demonstrated effectiveness in reducing seizure frequency when incorporated into a comprehensive treatment strategy.

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  • 155431-40-6 Structure
  • Basic information

    1. Product Name: 4-(2,4-Difluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
    2. Synonyms: 4-(2,4-Difluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one;4-(2,4-difluorophenyl)-2H-1,2,4-triazol-3(4H)-one
    3. CAS NO:155431-40-6
    4. Molecular Formula: C8H5F2N3O
    5. Molecular Weight: 197.14
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 155431-40-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.54
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 8.59±0.20(Predicted)
    10. CAS DataBase Reference: 4-(2,4-Difluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-(2,4-Difluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one(155431-40-6)
    12. EPA Substance Registry System: 4-(2,4-Difluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one(155431-40-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 155431-40-6(Hazardous Substances Data)

155431-40-6 Usage

Uses

Used in Pharmaceutical Industry:
4-(2,4-Difluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one is used as an antiepileptic agent for the treatment of Lennox-Gastaut syndrome, a severe form of epilepsy. It is utilized for its ability to modulate sodium channel activity in the brain, thereby stabilizing neuronal electrical activity and reducing the frequency of seizures.
The side effects of rufinamide may include dizziness, drowsiness, and nausea, and there is a potential for interaction with other medications. Therefore, its use should be carefully monitored by a healthcare professional to ensure safe and effective treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 155431-40-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,4,3 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 155431-40:
(8*1)+(7*5)+(6*5)+(5*4)+(4*3)+(3*1)+(2*4)+(1*0)=116
116 % 10 = 6
So 155431-40-6 is a valid CAS Registry Number.

155431-40-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2,4-difluorophenyl)-3(2H,4H)-1,2,4-triazolone

1.2 Other means of identification

Product number -
Other names 3H-1,2,4-TRIAZOL-3-ONE,4-(2,4-DIFLUOROPHENYL)-2,4-DIHYDRO-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:155431-40-6 SDS

155431-40-6Downstream Products

155431-40-6Relevant articles and documents

Azole compounds, their production and use

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, (2008/06/13)

An azole compound represented by the formula (I): STR1 wherein Ar is a substituted phenyl group; R1 and R2 independently are a hydrogen atom or a lower alkyl group, or R1 and R2 may combine together to form a lower alkylene group; R3 is a group bonded through a carbon atom; R4 is a hydrogen atom or an acyl group; X is a nitrogen atom or a methine group; and n Y and Z independently are a nitrogen atom or a methine group which may optionally be substituted with a lower alkyl group, or a salt thereof, which is useful for prevention and therapy of fungal infections of mammals as antifungal agent.

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