A new and general method for the synthesis of tripeptide aldehydes based on the multi-component Ugi reaction
Tripeptide aldehydes, such as Z-Leu-Leu-Leu-H (MG-132), are an important class of compounds due to their biological activity. A new, general method for the synthesis of tripeptide aldehydes based on the multi-component Ugi reaction was developed. A careful choice of isocyanides makes it possible to obtain tripeptide precursors whose functionalization led to target structures. This method can be used for the preparation of tripeptide aldehydes with non-natural amino acid side chains.
Amato, Francesco,Marcaccini, Stefano,Tangirala, Raghuram S.,Curran, Dennis P.
p. 18 - 21
(2017/09/08)
A FACILE SYNTHESIS OF 1-ARYL-2-ARYLTHIO-1H-IMIDAZOLES
The reaction between the hitherto unknown 2,2-diethoxy-1-isocyanoethane (1) with sulfenyl chlorides (2) and arylamines afforded isothioureas (4) which were cyclized to give the title compounds.
Bossio, Ricardo,Marcaccini, Stefano,Pepino, Roberto,Polo, Cecilia,Torroba, Tomas
p. 1287 - 1290
(2007/10/02)
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