155988-38-8

Basic information

• Product Name: 1-(2-NITROPHENYL)-2-NITROPROPENE
• Synonyms: 1-(2-NITROPHENYL)-2-NITROPROPENE
• CAS NO: 155988-38-8
• Molecular Formula: C9H8N2O4
• Molecular Weight: 208.17
• Mol File: 155988-38-8.mol

Chemical Properties

• Boiling Point: 356.7°C at 760 mmHg
• Flash Point: 176.5°C
• Appearance: /
• Density: 1.344g/cm³
• Vapor Pressure: 5.91E-05mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 1-(2-NITROPHENYL)-2-NITROPROPENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-NITROPHENYL)-2-NITROPROPENE(155988-38-8)
• EPA Substance Registry System: 1-(2-NITROPHENYL)-2-NITROPROPENE(155988-38-8)

Safety Data

• Hazardous Substances Data: 155988-38-8(Hazardous Substances Data)

Usage

Type of compound

Nitroalkene

Structure

Contains a nitro group and a carbon-carbon double bond

Usage

Commonly used in organic synthesis

Application

Building block for the preparation of various chemical compounds

Potential

Precursor in the synthesis of pharmaceuticals and agrochemicals

Studies

Investigated for potential use in the development of new materials and as a reagent in organic reactions

Safety

Handle with caution due to potential hazards and toxicity

InChI:InChI=1/C9H8N2O4/c1-7(10(12)13)6-8-4-2-3-5-9(8)11(14)15/h2-6H,1H3/b7-6+

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 14841-89-5 1-(2-nitrophenyl)-2-nitropropan-1-ol 
• 79-24-3 Nitroethane 

Downstream Products

• 1426682-60-1 2-methyl-3-(2-nitrophenyl)quinoxaline 
• 921-11-9 2,3,4-pentanetrione 
• 109704-02-1 Methyl<2,5-dimethyl-4-(2-nitrophenyl)-3-pyrrolyl>keton 
• 86396-16-9 methyl 2,3-dioxobutanoate 
• 95838-57-6 2,5-Dimethyl-4-(2-nitrophenyl)-3-pyrrolcarbonsaeure-methylester 

Relevant articles and documents

Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells

The implication of DNA methylation in cancer is today clearly established. Despite that nucleoside analogues are currently used for leukaemia treatment, their low stability in physiological conditions and their lack of selectivity arise the need for the i

THERAPEUTIC COMPOUNDS

no abstract published

Convenient modification of the Leimgruber-Batcho indole synthesis: Reduction of 2-nitro-p-pyrrolidinostyrenes by the FeCl3-activated carbon-N2H4H2O system

A new catalytic system containing ferric chloride, activated carbon, and hydrazine has been proposed for the reductive cyclization of β-dialkylamino-2-nitrostyrenes to give the corresponding indoles (Leimgruber-Batcho synthesis). Various substituted indoles may be obtained in high yield under these conditions.

Macrocyclic Compounds As Antiviral Agents

A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):

A general large scale synthesis of 2-alkyl-7-methoxyindoles

A general method has been developed for the large scale synthesis of 2-alkyl-7-methoxyindoles and analogs. This method involves an efficient preparation of the key intermediates, 1-(2-nitroaryl)-2-nitroalkanols and 1-(2-nitroaryl)-2-nitroalkenes, and affords 2-alkyl-7-methoxyindoles and analogs in 3 steps with good overall yields.

Compounds interacting with tubulin: Part I: Synthesis of ortho-ortho' substituted phenylpyrroles with free or restricted rotation.

The synthesis of ortho-ortho' substituted phenylpyrroles that are susceptible to isomerization of the biaryl type (atropisomerism) was performed using a Michael addition of isocyanoacetates with nitrostyrenes.Atropisomerism in phenylpyrroles 14 and 15 was studied by means of 1H NMR spectroscopy using chiral lanthanide shift reagents (LSR*).In the case of chiral phenylpyrrole 21, an evaluation of the interconversion parameters between diastereomers (k, ΔGT*) was attempted. - - - tubulin / phenylpyrrole / atropisomers / chiral shift reagents