156004-66-9

Basic information

• Product Name: (S)-N,3-diMethyl-1-(pyrrolidin-1-yl)butan-2-aMine
• Synonyms: (S)-N,3-diMethyl-1-(pyrrolidin-1-yl)butan-2-aMine
• CAS NO: 156004-66-9
• Molecular Formula: C₁₀H₂₂N₂
• Molecular Weight: 170.29508
• Mol File: 156004-66-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-N,3-diMethyl-1-(pyrrolidin-1-yl)butan-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N,3-diMethyl-1-(pyrrolidin-1-yl)butan-2-aMine(156004-66-9)
• EPA Substance Registry System: (S)-N,3-diMethyl-1-(pyrrolidin-1-yl)butan-2-aMine(156004-66-9)

Safety Data

• Hazardous Substances Data: 156004-66-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-N,3-diMethyl-1-(pyrrolidin-1-yl)butan-2-aMine is used as a building block for the synthesis of various drugs and pharmaceutical products. Its chirality plays a crucial role in drug development, as the different enantiomers can have distinct biological activities and effects.
Used in Chemical Intermediates:
In the chemical industry, (S)-N,3-diMethyl-1-(pyrrolidin-1-yl)butan-2-aMine may serve as a valuable chemical intermediate for the synthesis of other complex organic compounds, contributing to the development of novel materials and products.

Upstream product

• 56414-68-7 benzyl N-<(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl>carbamate 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 

Downstream Products

• 136328-73-9 N-Methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-2-phenylsulfanyl-acetamide 
• 115200-03-8 2-(3,4-Difluoro-phenyl)-N-methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-acetamide 
• 136328-69-3 N-Methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-2-(4-trifluoromethyl-phenyl)-acetamide 
• 136328-72-8 N-Methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-2-phenoxy-acetamide 
• 136328-67-1 2-(4-Chloro-phenyl)-N-methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-acetamide 
• 136328-65-9 N-Methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-2-phenyl-acetamide 
• 136328-71-7 N-Methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-3-phenyl-propionamide 
• 136328-66-0 2-(3-Chloro-phenyl)-N-methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-acetamide 
• 136328-70-6 2-(4-Methoxy-phenyl)-N-methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-acetamide 
• 136328-64-8 ICI 197067 
• 136328-68-2 N-Methyl-N-((S)-2-methyl-1-pyrrolidin-1-ylmethyl-propyl)-2-(4-nitro-phenyl)-acetamide 
• 1380102-10-2 (S)-1-(2-(4-chloro-N-methylbenzamido)-3-methylbutyl)pyrrolidinium chloride 

Relevant articles and documents

Enantioselective deprotonation of cyclohexene oxide to (R)-2-cyclohexen- 1-ol

The reaction of cyclohexene oxide with homochiral lithium amides, prepared from (S)-phenylglycine and (S)-valine has been studied and (R)-2-cyclohexen- 1-ol 3 was prepared in a maximum of 72% ee. The optical purity was determined by 1H NMR measurement of the α-methoxy-α-(trifluoromethyl)phenyl acetic acid (MTPA) derivative of the corresponding alcohol.

Structure/Activity Studies Related to 2-(3,4-Dichlorophenyl)-N-methyl-N-acetamides: A Novel Series of Potent and Selective κ-Opioid Agonists

This paper describes the synthesis of a series of N-acetamides 1, variously substituted at the carbon adjacent to the amide nitrogen (C1), and related analogues, together with their biological evaluation as opioid κ agonists.In the first part of the study, the variants in N-acyl, N-alkyl, and amino functions were explored when the substituent at C1 was 1-methylethyl and the optimum was found to be exemplified by 2-(3,4-dichlorophenyl)-N-methyl-N-acetamide (13).Subsequently, racemic or chiral amino acids were used to introduce other alkyl and aryl substituents at C1 of the ethyl linking moiety.A series of potent compounds, bearing substituted-aryl groups at C1, were discovered, typified by 2-(3,4-dichlorophenyl)-N-methyl-N-acetamide (48), which was 5-fold more active as the racemate than 13 in vitro and exhibited potent naloxone-reversible analgesic effects (ED50 = 0.04 mg/kg sc) in a mouse abdominal constriction model.