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3,4-dimethyl-7-(2-oxopropoxy)-2H-chromen-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 156006-10-9 Structure
  • Basic information

    1. Product Name: 3,4-dimethyl-7-(2-oxopropoxy)-2H-chromen-2-one
    2. Synonyms: 2H-1-benzopyran-2-one, 3,4-dimethyl-7-(2-oxopropoxy)-
    3. CAS NO:156006-10-9
    4. Molecular Formula: C14H14O4
    5. Molecular Weight: 246.2586
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 156006-10-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 412.3°C at 760 mmHg
    3. Flash Point: 184.8°C
    4. Appearance: N/A
    5. Density: 1.188g/cm3
    6. Vapor Pressure: 5.25E-07mmHg at 25°C
    7. Refractive Index: 1.541
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 3,4-dimethyl-7-(2-oxopropoxy)-2H-chromen-2-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3,4-dimethyl-7-(2-oxopropoxy)-2H-chromen-2-one(156006-10-9)
    12. EPA Substance Registry System: 3,4-dimethyl-7-(2-oxopropoxy)-2H-chromen-2-one(156006-10-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 156006-10-9(Hazardous Substances Data)

156006-10-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 156006-10-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,0,0 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 156006-10:
(8*1)+(7*5)+(6*6)+(5*0)+(4*0)+(3*6)+(2*1)+(1*0)=99
99 % 10 = 9
So 156006-10-9 is a valid CAS Registry Number.

156006-10-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4-dimethyl-7-(2-oxopropoxy)chromen-2-one

1.2 Other means of identification

Product number -
Other names 7-acetonyloxy-3,4-dimethylcoumarin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:156006-10-9 SDS

156006-10-9Downstream Products

156006-10-9Relevant articles and documents

Synthesis of Novel Anti-inflammatory Psoralen Derivatives?-?Structures?with?Distinct?Anti-Inflammatory?Activities

Timonen, Juri M.,Vuolteenaho, Katriina,Lepp?nen, Tiina,Nieminen, Riina M.,Aulaskari, Paula,J?nis, Janne,Vainiotalo, Pirjo,Moilanen, Eeva

, p. 2590 - 2597 (2018/09/25)

As a continuum to our work with coumarins, 12 psoralens were synthesized and evaluated for their anti-inflammatory activity. Psoralens were prepared in three steps; at first, 7-hydroxycoumarins were synthesized by von Pechmann condensation and then converted to 7-(2-oxopropoxy)coumarins. In the final step, a fused furan ring was introduced in an intramolecular ring-formation reaction. Based on a SciFinder search, two out of the 12 synthesized psoralen derivatives (compounds 9 and 12) were found to be novel. The derivatives displayed anti-inflammatory activity by suppressing iNOS and IL-6 expression, but their mechanism of action seemed to be dependent on the substitution. Compound 6 with propyl side chain inhibited NF-κB mediated transcription, while compound 10 with a phenyl substituent down-regulated iNOS expression in a posttranscriptional manner. The results introduce psoralen derivatives as promising anti-inflammatory compounds with potential for treatment of conditions involving iNOS and/or IL-6-mediated adverse responses.

7-(2-Oxoalkoxy)coumarins: Synthesis and Anti-Inflammatory Activity of a Series of Substituted Coumarins

Timonen, Juri,Vuolteenaho, Katriina,Lepp?nen, Tiina,Nieminen, Riina,Moilanen, Eeva,Aulaskari, Paula,J?nis, Janne

, p. 1286 - 1295 (2015/10/06)

A series of 7-(2-oxoalkoxy)coumarins have been synthesized by conjugating substituted 7-hydroxycoumarins with different chloroketones. The anti-inflammatory properties of 7-(2-oxoalkoxy)coumarins were studied in LPS-induced inflammatory response in J774 macrophages. Western blot was used to determine the expression of iNOS and COX-2, NO was determined by measuring its metabolite nitrite by Griess reaction and IL-6 was measured by ELISA. Seventeen of the studied compounds inhibited NO and IL-6 production over 50% at 100 μM concentrations. IC50 values of the best inhibitors were 21 μM/24 μM (NO/IL-6) for compound 12 and 30 μM/10 μM (NO/IL-6) for compound 20. The main result was that the substitution with 7-(2-oxoalkoxy) group improved the anti-inflammatory properties of most of the investigated 7-hydroxycoumarins.

Synthesis and characterization of new methylpsoralens as potential photochemotherapeutic agents

Antonello,Zagotto,Mobilio,Marzano,Gia,Uriarte

, p. 277 - 280 (2007/10/02)

Three new psoralens with methyl groups on carbons involved in their reactive double bonds (compounds 9-11 in Scheme 1) were synthesized from the corresponding 7-hydroxycoumarins by cyclization of acetonyl derivatives of the latter in an alkaline medium. In preliminary tests, the new methyl-substituted psoralens exhibited considerable interaction in the dark with DNA, good photoreactivity against the macromolecule, and also interesting antiproliferative activity.

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