- Asymmetric phase-transfer catalyzed glycolate alkylation, investigation of the scope, and application to the synthesis of (-)-ragaglitazar
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Asymmetric glycolate alkylation using a protected acetophenone surrogate under solid-liquid phase-transfer conditions is a new approach to the synthesis of 2-hydroxy esters and acids. Diphenylmethyloxy-2,5-dimethoxyacetophenone 1 with a trifluorobenzyl ci
- Andrus, Merritt B.,Hicken, Erik J.,Stephens, Jeffrey C.,Karl Bedke
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p. 9470 - 9479
(2007/10/03)
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- AMIDE LINKER PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
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The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I).
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- Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
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A compound of formula (1) it derivatives, its analogs, its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts, or its pharmaceutically acceptable solvates, processes for its preparation and methods of use thereof.
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- Process for the preparation of 3-aryl-2-hydroxy propanoic acid
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The present invention relates to an improved process for the preparation of 3-aryl-2-hydroxy propanoic acid derivatives of the formula (1) 1useful as an intermediate for the preparation of many pharmaceutically active compounds.
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- Competing O - H insertion and β-elimination in rhodium carbenoid reactions; synthesis of 2-alkoxy-3-arylpropanoates
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Rhodium(II) carboxylate catalysed decomposition of diazo esters 3 and 4 in the presence of alcohols or water results in formation of 2-alkoxy- or 2-hydroxy-3-arylpropanoates respectively by O - H insertion in competition with cinnamates by elimination; the ratio of insertion to elimination is dramatically affected by the carboxylate ligand on rhodium. Use of methanol-d as the alcohol confirms that the alkene does not arise by elimination from the initial alkoxyester product.
- Cox, Geoffrey G.,Haigh, David,Hindley, Richard M.,Miller, David J.,Moody, Christopher J.
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p. 3139 - 3142
(2007/10/02)
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