156337-47-2Relevant articles and documents
Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles
Xu, Wei,Mohan, Raju,Morrissey, Michael M.
, p. 1089 - 1092 (2007/10/03)
A convenient solution-phase method for N-alkylation reactions of weakly acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N- alkylation sequences can be carried out in a one-pot process.
Alpha1a adrenergic receptor antagonists
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, (2008/06/13)
Compounds that specifically bind to the human alpha1a adrenergic receptor, including compounds effective to reduce symptoms of benign prostatic hypertrophy include compounds of formula: STR1 wherein: Ar1 and Ar2 can be independantly aromatic, heteroaromatic, or condensed heteroaromatic unsubstituted or substituted with amino, alkoxy, sulfonamido, alkyl, heteroalkyl, halo;m is 0 or 1;n is 0, 1, or 2;het is an aromatic or nonaromatic heterocyclic ring, substituted with alkyl, halo, or alkoxy substituents; andX is a branched or straight chain aliphatic or halogen substituent.
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor
Rowley, Michael,Collins, Ian,Broughton, Howard B.,Davey, William B.,Baker, Raymond,Emms, Frances,Marwood, Rosemarie,Patel, Shil,Patel, Smita,Ragan, C. Ian,Freedman, Stephen B.,Ball, Richard,Leeson, Paul D.
, p. 2374 - 2385 (2007/10/03)
5-(4-Chlorophenyl)-3-(1-(4-chlorobenzyl)piperidin-4-yl)pyrazole (3) was identified from screening of the Merck sample collection as a human dopamine D4 (hD4) receptor ligand with moderate affinity (61 nM) and 4-fold selectivity over human D2 (hD2) recepto
DOPAMINE RECEPTOR SUBTYPE LIGANDS
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, (2008/06/13)
Compounds of formula (I) STR1 wherein one of X and Y represents nitrogen, and the other of X and Y represents oxygen, sulphur or N--R 2 ; Q represents a substituted five-or six-membered monocyclic heteroaliphatic ring which contains one nitrogen atom as t