Pyridylthiobarbiturates and their antidepressant activity
5-Arylidene-1-aryl-3-(2-pyridyl)thiobarbituric acids (3a-e) and 1-aryl-5-N-arylaminomethyl-3-(2-pyridyl)thiobarbituric acids (4a-f) have been synthesized from 1-aryl-3-(2-pyridyl)thiobarbiturates (2) by condensation with aryl aldehydes and with arylamine and formaldehyde respectively.Compounds 4b and 4c exhibit antidepressant activity.
Shalmashi, A.,Palit, G.,Srivastava, V. K.,Shanker, K.
p. 597 - 599
(2007/10/03)
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