Strecker reactions with hexacyanoferrates as non-toxic cyanide sources
The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium ferri- and ferrocyanides as a non-toxic substitute.
Grundke, Caroline,Opatz, Till
supporting information
p. 2362 - 2366
(2019/05/17)
Open-Chain Reissert Compounds: One-Pot Synthesis and Utility in Synthesis of Unsymmetrical Imides, α-Acylamino Carboxamides, Imidazolinones, and Hydantoins
Acyclic Reissert compounds 2 and bis(Reissert compound)s 3-5 can be conveniently prepared in a biphasic system without isolation of the intermediate α-amino nitriles.Treatment of 2 with sodium hydride affords substituted unsymmetrical imides as 8.Oxidativ
Leblanc, Jean-Pierre,Gibson, Harry W.
p. 1072 - 1077
(2007/10/02)
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