Facile synthesis of (R,S)-(Z) and (R,S)-(E)-N-methyl-(10,11-dihydro-10- hydroxy-5H-dibenzo[a,d]cycloheptene)-Δ(5,γ)-propylamine the major metabolites of amitriptyline and nortriptyline
Efficient methods for the syntheses of amines 6b and 9b, the major metabolites of the antidepressant drugs amitriptyline 1a and nortriptyline 1b, are described.
Jean-Claude,Just
p. 1565 - 1573
(2007/10/02)
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