156459-82-4Relevant articles and documents
CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS
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Page/Page column 126-127, (2017/12/01)
The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds can inhibit both LSD and HDAC and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, parkinson's disease and the like.
Synthesis and NMR Characterization of 4-piperidine and Intermediates
Petric, Andrej,Barrio, Jorge R.
, p. 545 - 548 (2007/10/02)
4-(Hydroxymethyl)piperidine was selectively protected with tetrahydropyranyl group in several steps to give the title compound.Use of 1H and 19F nmr spectra in structure determination is discussed.