A copper-catalyzed coupling reaction of vinyl halides and carbazates: Application in the assembly of polysubstituted pyrroles
CuI-catalyzed coupling of vinyl halides with carbazates gives N-protected N-alkenylhydrazines, which are condensed with ketones under acidic conditions to give polysubstituted pyrroles. The pyrrole synthesis may go through a similar mechanism with Fischer indole synthesis, which involves a [3,3]-sigmatropic rearrangement and other reactions. The Royal Society of Chemistry.
Zhou, Chengang,Ma, Dawei
supporting information
p. 3085 - 3088
(2014/03/21)
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