156810-04-7Relevant articles and documents
COMPOUNDS INTERACTING WITH THE NEUROEXCITATORY AMINO ACIDS: SYNTHESIS OF 2-(4-ARALKYLPIPERAZINE-1-YL)-1-ARYLETHANOLS
Silhankova, Alexandra,Dobrovsky, Karel,Krejci, Ivan,Polivka, Zdenek
, p. 658 - 666 (1994)
Amino ketones Ia - If and III were synthesized.Their reduction gave corresponding alcohols IIa - IIf, IVa and IVb.These were evaluated by methods of biochemical and behavioural pharmacology.
Phenyl piperazine derivative and its preparation and use
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Paragraph 0022-0027, (2016/10/10)
The invention belongs to the field of organic synthesis, and particularly relates to phenylpiperazine derivatives as well as a preparation method and applications thereof. The preparation method comprises the steps of putting 2,4'-dibromoacetophenone, sub
Discovery of phenylpiperazine derivatives as IGF-1R inhibitor with potent antiproliferative properties in vitro
Guo, Feng-Jiao,Sun, Juan,Gao, Li-Li,Wang, Xin-Yi,Zhang, Yang,Qian, Shao-Song,Zhu, Hai-Liang
, p. 1073 - 1077 (2015/02/19)
A series of phenylpiperazine derivatives (3a-3q) were designed and synthesized. In vitro assays indicated that several phenylpiperazine derivatives had excellent antiproliferative properties against four cancer cell lines including multidrug-resistant can
Synthesis and structure-activity relationships of 2-(4-benzhydryl-1-piperazinyl)-1-phenylethanols as new calcium blockers
Nomura,Yamakawa,Nishioka,Omura,Miyake,Masaki,Nohira
, p. 241 - 246 (2007/10/02)
A series of 2-(4-benzhydryl-1-piperazinyl)-1-phenylethanols (4) was synthesized and evaluated for calcium entry-blocking activity, assessed as inhibitory activity on calcium current in rat hippocampal pyramidal neurons by using a patch-clamp technique (10