The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof for use in the treatment of cancer:
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(2014/03/25)
Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines
The metal-dependent phosphatase PPM1D (WIP1) is an important oncogene in cancer, with over-expression of the protein being associated with significantly worse clinical outcomes. In this communication we describe the discovery and optimization of novel 2,4
Cheeseman, Matthew D.,Faisal, Amir,Rayter, Sydonia,Barbeau, Olivier R.,Kalusa, Andrew,Westlake, Maura,Burke, Rosemary,Swan, Michael,Van Montfort, Rob,Linardopoulos, Spiros,Jones, Keith
p. 3469 - 3474
(2014/07/22)
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