- Thrombopoietin mimetics
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Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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Page column 31-32
(2008/06/13)
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- New Heterocyclic compounds for therapeutic use
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A class of compounds particularly diaryl pyrazole of general formulas 1 and 2 where R and R′ represents alkyl, hydrogen, halogens, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulphonyl, N- alkylsulfamyl, N-arylsulfamyl, cyanoamido, amino, amidino, N-monoalkylamido, N-monoarylamido, N,N-dialkylamido, N-alkyl-N-arylamido, N, N-dialkylsulfamyl with the alkyl, or alkyl part of each such group containing 1-3 carbon atoms or mixtures thereof optionally their salts when they exist, and preparation thereof. The compounds of the present invention are antiinflammatory, antipyretic, antirheumatic, antiosteoarthritic agents with antibacterial activity. The particular class of compounds is given below (Formula 1 and Formula 2).
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- INTERMEDIATES TO TETRAHYDRO-BETA-CARBOLINES
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3-Ethanamine and 3-ethanamine related compounds are provided that are useful intermediates and have beneficial central nervous system activity.
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- METHOD FOR TREATING 5HT2B RECEPTOR RELATED CONDITIONS
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The present invention provides methods for binding a 5-HT 2B receptor in mammals using a both known and novel compounds. Further, the invention provides a method for treating or preventing 5-HT 2B related conditions. Finally, the invention provides an article of manufacture.
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- TETRAHYDRO-PYRIDO-INDOLE
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The present invention provides pentacyclic pyrido[3,4-b] indoles having useful central nervous system activity.
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- Tetrahydro-β-carbolines
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The present invention provides tetrahydro-betacarboline compounds having useful central nervous system activity.
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- Tetrahydro-pyrido-indole
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The present invention provides a new Pictet-Spengler process useful for preparing tetrahydro-beta-carboline compounds.
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