15718-51-1

Basic information

• Product Name: CYCLIC CYTIDYLIC ACID SODIUM SALT
• Synonyms: CYCLIC CYTIDYLIC ACID SODIUM SALT;Cytidine 2,3-cyclic monophosphate monosodium salt;cytidine 2:3-cyclic monophosphate*sodium;Cytidine, cyclic 2',3'-(hydrogen phosphate), monosodium salt;CYTIDINE 2' 3'-CYCLOPHOSPHATE &;2μ,3μ-Cyclic CMP monosodium salt, Cyclic cytidylic acid, Cytidine 2μ,3μ-cyclophosphate sodium salt;Cytidine 2',3'-phosphatesodium salt;Cytidine 2',3'-phosphoric acid sodium salt
• CAS NO: 15718-51-1
• Molecular Formula: C₉H₁₁N₃O₇P*Na
• Molecular Weight: 327.16
• EINECS: 239-813-2
• Mol File: 15718-51-1.mol

Chemical Properties

• Boiling Point: 568.5 °C at 760 mmHg
• Flash Point: 297.6 °C
• Appearance: /
• Density: 2.28 g/cm³
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• BRN: 4086446
• CAS DataBase Reference: CYCLIC CYTIDYLIC ACID SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLIC CYTIDYLIC ACID SODIUM SALT(15718-51-1)
• EPA Substance Registry System: CYCLIC CYTIDYLIC ACID SODIUM SALT(15718-51-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 1-10
• Hazardous Substances Data: 15718-51-1(Hazardous Substances Data)

Usage

Uses

Used in Enzymatic Synthesis:
CYCLIC CYTIDYLIC ACID SODIUM SALT is used as a key compound in the enzymic synthesis of short oligoribonucleotides for facilitating the formation of these essential molecules in various biological processes.
Used in Research and Development:
CYCLIC CYTIDYLIC ACID SODIUM SALT is used as a model substrate for kinetic analysis of various ribonucleases, especially ribonuclease A, to study the mechanisms and properties of these enzymes in molecular biology research.
Used in Pharmaceutical Industry:
CYCLIC CYTIDYLIC ACID SODIUM SALT is used as a research tool for the development of new drugs and therapies, particularly in the areas of molecular biology and biotechnology, due to its involvement in the synthesis of oligoribonucleotides and its potential applications in gene regulation and other cellular processes.
Used in Diagnostics:
CYCLIC CYTIDYLIC ACID SODIUM SALT can be employed in the development of diagnostic tools and tests, as its interaction with ribonucleases and other enzymes can provide valuable information about the presence and activity of specific biological molecules in a sample.

Synthetic route

CYTIDINE (65-46-3) → cytidine 2′,3′-cyclic monophosphate sodium salt (15718-51-1)

Conditions	Yield
With 1H-imidazole; sodium diamido phosphate; water at 20℃; for 240h; pH=5.5;	42%

cytidine-3'-monophosphate dinatrium salt → cytidine 2′,3′-cyclic monophosphate sodium salt (15718-51-1)

Conditions	Yield
With sodium diamido phosphate; water

C9H12N3O8P(2-)*2Na(1+) → cytidine 2′,3′-cyclic monophosphate sodium salt (15718-51-1)

Conditions	Yield
With sodium diamido phosphate; water

[Ru2Cl2(N,N′‑diphenylformamidinate)3] + cytidine 2′,3′-cyclic monophosphate sodium salt (15718-51-1) → [Ru2Cl(N,N′‑diphenylformamidinate)3(cytidine-2′,3′-cyclic monophosphate monoanion)]

Conditions	Yield
In methanol at 20℃; for 25h;	64%

Upstream product

• 65-46-3 CYTIDINE 

Relevant articles and documents

Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions

Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP) - a plausible prebiotic agent produced from trimetaphosphate - efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment.