Copper-catalyzed N-arylation of the adduct of malononitrile and trichloroacetonitrile
The synthesis of a novel class of trichloro-1-{(N-arylamino)ethylidene}malononitrile via a copper-catalyzed multicomponent reaction of malononitrile-trichloroacetonitrile adduct and aryl hal-ides in good yields is described. The reported protocol has some advantages such as simple and mild procedure, easy work-up, no column chromatography, available starting materials-catalyst, pure products and good to high yields.
A convenient procedure is reported for the one-pot preparation of enaminedinitriles.This involves the sodium methoxide-catalysed addition of methanol to a suitably substituted nitrile followed by reaction of the resulting imidate with malononitrile.The mechanism, scope and limitations of the synthesis have been investigated.Spectroscopic evidence is presented that the products exist in the enaminedinitrile rather than in the tautomeric imino form.Various reactions of the compounds including halogen exchange, anion formation and amine displacement have been studied and used to extend the range of enaminedinitriles prepared.
Berry, Robert W. H.,Drewry, Peter C.,Hodson, Harold F.
p. 958 - 975
(2007/10/02)
More Articles about upstream products of 1572-57-2