157220-77-4Relevant articles and documents
The synthesis and antibacterial activity of totarol derivatives. Part 2: Modifications at C-12 and O-13
Evans, Gary B.,Furneaux, Richard H.
, p. 1653 - 1662 (2007/10/03)
Alterations of the C-12 and C-13 aromatic ring substituents of totarol (1) afforded the series of derivatives 2-14, and introduction of substituents at C-12 gave exclusively 2a-14a. The majority of these analogues were tested in vitro against the following organisms: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. The results were evaluated in terms of structure-activity relationship which reveals that: (a) the phenolic moiety at C-13, in general, is essential for antibacterial activity at 32 μg/mL against Gram-positive species, and (b) derivatization at C-12 has an undesirable effect on the antibacterial activity of this class of compounds, while (c) all compounds tested are ineffective against the Gram-negative Klebsiella pneumoniae. Copyright (C) 2000 Elsevier Science Ltd.
Copper(I)-Mediated Oxygenation of Diterpenoids; Three Routes to Catechol Derivatives
Bendall, Justin G.,Cambie, Richard C.,Rutledge, Peter S.,Stevenson, Ralph J.,Woodgate, Paul D.
, p. 487 - 500 (2007/10/02)
Derivatives of totarol (1) and podocarpic acid (8) have been oxygenated in ring C via their corresponding carbamates, or aryl bromides, to form catechol derivatives.These oxygenations have been accomplished by the use of copper(I), both in stoichiometric
