157359-99-4

Basic information

• Product Name: 2-Chloro-6-fluorophenacyl bromide 98%
• Synonyms: 2-Chloro-6-fluorophenacyl bromide 98%;2-Bromo-2'-chloro-6'-fluoroacetophenone, 2-Bromo-1-(2-chloro-6-fluorophenyl)ethan-1-one;2-fluoro-6-chlorophenacylbroMide;2-Bromo-1-(2-chloro-6-fluorophenyl)ethanone;2-BroMo-2'-chloro-6'-fluoroacetophenone;2-Chloro-6-fluorophenacylbromide98%
• CAS NO: 157359-99-4
• Molecular Formula: C₈H₅BrClFO
• Molecular Weight: 251
• Mol File: 157359-99-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Chloro-6-fluorophenacyl bromide 98%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-fluorophenacyl bromide 98%(157359-99-4)
• EPA Substance Registry System: 2-Chloro-6-fluorophenacyl bromide 98%(157359-99-4)

Safety Data

• Hazardous Substances Data: 157359-99-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-fluorophenacyl bromide 98% is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the creation of fluorinated compounds, which often possess enhanced pharmacological properties such as increased lipophilicity, metabolic stability, and bioavailability.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Chloro-6-fluorophenacyl bromide 98% serves as a versatile reagent, facilitating a range of reactions that lead to the formation of complex organic molecules. Its use is particularly beneficial in the development of new chemical entities and the improvement of existing synthetic routes.
Used in Chemical Research:
2-Chloro-6-fluorophenacyl bromide 98% is also utilized in chemical research as a tool to explore novel reaction mechanisms and to develop innovative synthetic methodologies. Its reactivity and selectivity make it a valuable probe in understanding and optimizing chemical processes.
Used in the Production of Fluorinated Compounds:
2-Chloro-6-fluorophenacyl bromide 98% is used as a precursor in the production of fluorinated compounds, which are important in various applications due to their unique properties. The introduction of fluorine atoms can significantly alter the physical, chemical, and biological characteristics of molecules, making them suitable for a wide range of uses, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 87327-69-3 1-(2-chloro-6-fluorophenyl)ethan-1-one 

Downstream Products

• 1333906-50-5 2-((9H-purin-6-yl)thio)-1-(2-chloro-6-fluorophenyl)ethanone 

Relevant articles and documents

METHODS OF USE FOR OPSIN BINDING LIGANDS

Methods of use of compounds of the Formula I1 II, III, IV and/or V are disclosed for treating ophthalmic conditions related to the production of toxic visual cycle products that accumulate in the eye, and are associated with reactions of the visual cycle during medical procedures that expose the eye to light, most commonly the various forms of ophthalmic surgery and stabilize the proper folding of mutant opsins. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said treatments.

ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES

Aminothiazole compounds substituted with sulfur-containing groups are represented by the Formula (I), and their pharmaceutically acceptable salts, prodrugs, active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use

Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

A new approach to the synthesis of 2-aminoimidazo[1,2-a]pyridine derivatives through rapid parallel synthesis

Different substituted 6-(2,6-difluorobenzoyl)-imidazopyridines 3 have been prepared using rapid parallel synthesis. Key cyanamide intermediate 4 was prepared from chloropyridine 1, and alkylated at the endocyclic nitrogen with different bromoacetophenones (prepared also in rapid parallel synthesis fashion). Subsequent cyclization was performed in situ with EtOAc/H2O to give target molecules.