- Kinetics and mechanism of oxidation of sarcosine by diperiodatocuprate(III) complex in alkaline medium
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The kinetics of oxidation of sarcosine by diperiodatocuprate(III) (DPC) was studied with spectrophotometry in a temperature range of 292.2-304.2 K. The reaction between diperiodatocuprate(III) and sarcosine in alkaline medium exhibits 1:1 stoichiometry (DPC: sarcosine). The reaction was found to be first order with respect to both DPC and sarcosine. The observed rate constant (k obs) decreased with the increase of the [IO-4], decreased with the increase of the [OH], and then increased with the increase of the [OH] after a turning point. There was no salt effect, and free radicals were detected. Based on the experimental results, a mechanism involving the diperiodatocuprate(III) (DPC) as the reactive species of the oxidant has been proposed. The activation parameters, as well as the rate constants of the rate-determining step, have been calculated.
- Shan, Jinhuan,Wang, Xiaoqian,Zhao, Ning,Shen, Haixia
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- Synthesis of substituted 2-(2-oxopyrrolidin-1-yl)acetamides
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The reaction of chloroacetamide with 2 equiv of γ-aminobutyric acid potassium salts provides a convenient method for the synthesis of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids. Alkylation products of 2-aminoacetic and 3-aminopropanoic acid with chloroacetamide were isolated. Thermal cyclization of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids afforded 2-(2-oxopyrrolidin-1-yl)acetamides.
- Kavina,Sizov,Yakovlev
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p. 873 - 878
(2017/08/02)
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- Octahydro-2H-pyrrolo[3,4-g]quinolines
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Octahydro-2H-pyrrolo[3,4-g]quinolines, useful as dopamine agonists, particularly as inhibitors of prolactin secretion and in treatment of Parkinsonism.
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- Tetrahydro-2H-benzo[c]pyrroles
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Tetrahydro-2H-benzo[c]pyrroles, useful as dopamine agonists, particularly as inhibitors of prolactin secretion and in treatment of Parkinson's syndrome.
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