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157518-70-2

(2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID is a chiral molecule with a molecular formula of C12H20O5. It is a derivative of valeric acid, featuring a dioxolane ring and a stereocenter at the second carbon atom. (2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID is utilized in the pharmaceutical industry as a key building block for the synthesis of a variety of drugs, particularly those with antiviral and antifungal properties. Its potential biological and pharmacological activities make it a valuable subject of interest in medicinal chemistry research.
Used in Pharmaceutical Industry:
(2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID is used as a building block for the synthesis of various drugs due to its unique structural features and chiral properties. It plays a crucial role in the development of antiviral and antifungal agents, contributing to the creation of effective medications to combat viral and fungal infections.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID is used for exploring its potential biological and pharmacological activities. Researchers investigate its interactions with biological targets and its capacity to modulate specific pathways, which can lead to the discovery of new therapeutic agents and a deeper understanding of its mechanisms of action.

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  • 157518-70-2 Structure

  • Basic information

    1. Product Name: (2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID
    2. Synonyms: (2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID;(R)-2-((S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)-4-methylpentanoic acid(WXG01078);(R)-2-((S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)-4-methylpentanoic acid
    3. CAS NO:157518-70-2
    4. Molecular Formula: C11H18O5
    5. Molecular Weight: 230.26
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 157518-70-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID(157518-70-2)
    11. EPA Substance Registry System: (2R)-4-METHYL-2-[(S)-2,2-DIMETHYL-5-OXO-1,3-DIOXOLAN-4-YL]VALERIC ACID(157518-70-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 157518-70-2(Hazardous Substances Data)

157518-70-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 157518-70-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,5,1 and 8 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 157518-70:
(8*1)+(7*5)+(6*7)+(5*5)+(4*1)+(3*8)+(2*7)+(1*0)=152
152 % 10 = 2
So 157518-70-2 is a valid CAS Registry Number.

157518-70-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid

1.2 Other means of identification

Product number -
Other names 2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:157518-70-2 SDS

157518-70-2Relevant articles and documents

METALLOPROTEINASE INHIBITORS

-

Page 24, (2010/02/09)

Compounds formula (IA) or (IB); wherein W represents HO(C=0)-, HONH(C=0)- or H(C=O)N(OH)-; X represents -O- or -S-; and R1, R2, and R3 are as defined in the description and claims, are inhibitors of matrix metalloproteinases, in particular MMP9 and/or MMP12.

Matrix metalloproteinase inhibitors: A structure-activity study

Levy, Daniel E.,Lapierre, France,Liang, Weisheng,Ye, Wenqing,Lange, Christopher W.,Li, Xiaoyuan,Grobelny, Damian,Casabonne, Marie,Tyrrell, David,Holme, Kevin,Nadzan, Alex,Galardy, Richard E.

, p. 199 - 223 (2007/10/03)

Modifications around the dipeptide-mimetic core of a hydroxamic acid based matrix metalloproteinase inhibitor were studied. These variations incorporated a variety of natural, unnatural, and synthetic amino acids inaddition to modifications of the P1' and P3' substituents. The results of this study indicate the following structural requirements: (2) Potent inhibitorsmust possess string zinc-binding functionalities. (3) The potential importance of the hydrophobic group at position R3 as illustratedby itsability to impart greater relative potency against stromelysin when larger hydrophobic groups are used. (4) Requirements surrounding the nature of the amino acid appear to be more restrictive for stromelysin than for neutrophil collagenase, 72 kDa gelatinase, and 92 kDa gelatinase. These requirements may involve planar fused-ring aryl systems and possibly hydrogen-bonding capabilities.

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