157524-19-1

Basic information

• Product Name: diethyl benzylpiperazinomethylphosphonate
• Synonyms: diethyl benzylpiperazinomethylphosphonate
• CAS NO: 157524-19-1
• Molecular Formula: C₁₆H₂₇N₂O₃P
• Molecular Weight: 326.3709
• Mol File: 157524-19-1.mol

Chemical Properties

• Boiling Point: 426.3°Cat760mmHg
• Flash Point: 211.6°C
• Appearance: /
• Density: 1.122g/cm³
• Vapor Pressure: 1.78E-07mmHg at 25°C
• Refractive Index: 1.519
• PKA: 6.62±0.10(Predicted)
• CAS DataBase Reference: diethyl benzylpiperazinomethylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl benzylpiperazinomethylphosphonate(157524-19-1)
• EPA Substance Registry System: diethyl benzylpiperazinomethylphosphonate(157524-19-1)

Safety Data

• Hazardous Substances Data: 157524-19-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H27N2O3P/c1-3-20-22(19,21-4-2)15-18-12-10-17(11-13-18)14-16-8-6-5-7-9-16/h5-9H,3-4,10-15H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 2759-28-6 1-phenylmethylpiperazine 
• 598-02-7 Diethyl phosphate 
• 83991-49-5 1-[(4-benzylpiperazin-1-yl)methyl]-1H-benzo[d][1,2,3]triazole 
• 122-52-1 triethyl phosphite 

Relevant articles and documents

Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives

A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824) and Escherichia coli (MTCCB 1652), and antifungal activity against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds 4d and 6a showed very less toxicity against human erythrocytes.

4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases

The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the steroisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.